Product

A. Overview

GABA is a substance that exists in the human body and is involved in neurotransmission with glutamic acid.GABA was first discovered in potato tubers in 1949 by Steward, Thompson, & Dent. In a year later GABA was also found in the brain of mammals. Late 1950s it was a puzzle that GABA content of CNS was much higher than that of other organ. In animals, it is present in the brain, kidney, heart and lungs. In plants, it is present in the leaves, stems and roots. Signal transduction in the human brain is carried out by the glutamic acid, an excitatory neurotransmitter.

Effect on the human body
GABA plays an important role in regulating neuronal excitability throughout the nervous system and has several well-known physiological functions.GABA is linked with several psychiatric and neurological disorders, such as anxiety, pain, depression, insomnia and epilepsy. In addition, GABA has hypotensive, sedative, diuretic and antidiabetic effects, regulates lipid levels in serum, inhibits the proliferation of cancer cells and improves memory and learning ability. Along with the GABA shunt, GABA was also synthesized via the polyamine route. GABA also acts as a solid substance in response to various stressors such as mechanical, stimuli, hypoxia, cellular oxidation, water, darkness, drought and salt stressors.

Due to the beneficial effects of GABA, the demand is currently seeing an increase. GABA is classified as a bioactive ingredient and has significant use in food and pharmaceutical drugs. Various traditional foods containing GABA obtained through microbial fermentation are safe and eco-friendly. The demand for healthful foods rich in GABA can be met by producing GABA in living organisms.

MH2 Biochemical Co., Ltd. is producing competitive high-purity GABA by introducing manufacturing technology of lactic acid bacteria in kimchi (patent number:) combined with excellent GABA production capacities and existing separation and purification technology.

C. Distribution

A. Overview

Citrulline is not a protein-forming amino acid, but exists widely in living organisms in a free state. It was detected in the juice of watermelon in 1914 and its name was derived from the Latin word for watermelon, citrullus. Citrulline is involved in converting ammonia, a toxic substance produced by amino acid metabolism, into harmless urea in the urea cycle. Ammonia and carbon dioxide are combined with ornithine to form citrulline. Citrulline produces arginine in the presence of aspartic acid and ATP. Arginine is again decomposed into urea and ornithine and urea is excreted from the body by the kidneys.

Arginine, a component of protein, also plays an important role in protecting the body from the outside by producing nitric oxide. It is involved in the erection of the penis during sexual activity. When arginine is ingested as food, a significant portion is decomposed into ornithine in the intestine, but when ingested as citrulline, it is converted into arginine in the kidneys. The citrulline gives rise to elevate nitric oxide higher than arginine.

C. Distribution

A. Overview

Theanine is a non-protein amino acid that was discovered in 1940 by Sakato in Japan. Theanine is also found in some mushrooms, but most of it is contained in tea plants in Camellia trees. Synthesis of theanine in tea plants start mainly in the roots. It is later transmitted through the stems to the leaves. Usually, the theanine content in leaves is one to three percent, but it varies depending on the time of leaf picking. Theanine is relatively stable in aqueous solution and has a slightly sweet taste, which has a synergistic effect with other flavor enhancers such as MSG, IMP and GMP.

There are many reports that theanine is effective in reducing stress, improving learning abilities, preventing coronary artery disease, reducing weight and enhancing immunity. Orally ingested theanine is absorbed in the intestine and delivered to various parts of the body with blood. Theanine delivered to the brain emits an alpha wave, which is a sign of stress reduction. There are also reports that ingesting theanine with caffeine enhances learning abilities. Several reports suggest that theanine may increase the palatability of food and may also benefit health and improve cognitive abilities.

C. Distribution

A. Overview

L-Ornithine-L-Aspartate is used to treat liver disease, such as hepatitis, cirrhosis and encephalopathy. Since developed by Merz Co. (Germany) early seventies, it is widely used in approximately 70 countries, and is enlisted in the Korean Pharmacopoeia.

Ornithine is involved in urea cycle to excreting harmful ammonia produced as a result of protein metabolism from the human liver in the form of urea. Aspartic acid is converted into glutamic acid and helps reduce ammonia in the blood by converting the excess ammonia into glutamine.